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500 Solutions

No problem is ever permanently closed. The editor is always pleased to consider for publication new solutions or new insights o n p a s t p r oblems. (1) Determine the set of all c > 0 such that whenever (1) holds, then we have x + y + z xy + yz+ zx. The positive r eals c asked for are those satisfying c 4. From (1), we have xy < c and z = c ; xy x + y + xy. Substituting this value of z into th...

500 [پانصد] خودنگاره

Mol081083 490..500

Membrane transporter proteins may influence the sensitivity of cancer cells to anticancer drugs that can be recognized as substrates. The purpose of this study was to identify proteins that play a key role in the drug sensitivity of stomach and breast cancer cell lines by measuring the absolute protein expression levels of multiple transporters and other membrane proteins and examining their co...

C4nr03962a 500..510 ++

Tumor associated macrophages (TAMs) can modify the tumor microenvironment to create a pro-tumor niche. Manipulation of the TAM phenotype is a novel, potential therapeutic approach to engage anticancer immunity. siRNA is a molecular tool for knockdown of specific mRNAs that is tunable in both strength and duration. The use of siRNA to reprogram TAMs to adopt an immunogenic, anti-tumor phenotype ...

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